Miss Ida Ingram's dying wish was to have her ashes scattered over the Grand Canyon - no small request for the two remaining sisters, Isabelle and Imogene, as they are elderly and have never before ventured out of South Carolina. Into the picture comes a long-lost nephew, Brandon, who agrees to drive his maiden aunts to Arizona to give himself time to think through his own mid-life crisis. Leigh Ann, a young neighbor woman who was practically raised by the elderly triplets, soon catches up and joins them on this incredible trip where they meet everyone from a crooked mechanic to a cross-dresser named Barbie who saves the day in New Orleans. The elderly women also learn about converter boxes, margaritas, and how much trouble an urn of ashes can be. Hilarious at times, it's a poignant journey, a discovery of the soul. At the rim of the Grand Canyon, they realize Ida's final request was really a blessing.